Neuropathy and Pain
Chris Arnatt Ph.D.
Chris Arnatt utilizes organic and synthetic chemistry to generate targeted small molecules for research and therapy. He has a special interest in developing chemical and fluorescent probes to study biologic systems, and focuses his research on nuclear proteins and DNA modifications in cancer and stem cell biology.
Keywords:Breast Cancer, GPCRs, Synthetic Chemistry
Sergey Korolev Ph.D.
Sergey Korolev uses structural, biochemical, and molecular biology methods to study the structure and function of DNA recombination mediator proteins. Human RMPs include tumor suppressors BRCA1/2 and PALB2, while pathogen RMPs mediate drug resistance. His lab also studies the calcium-independent phospholipase iPLA2B, a protein implicated in obesity, cancer, infantile neuroaxonal dystrophy, and Parkinsons.
Keywords: Chronic Pain, Parkinson’s, Tumor Suppression
Daniella Salvemini, Ph.D.
Daniella Salvemini focuses her work on discovery and development of non-opioid pain relief. Using multi-diciplinary approaches including genetic, molecular, and pharmacological tools, her lab studies how neuro-inflammatory process impact periphery and CNS during chronic pain. Her discoveries in adenosine A3 receptor signaling pathway have been licensed to BioIntervene, which she helped found.
Keywords:Chronic Pain, Pharmacology
Gina Yosten, Ph.D.
Gina Yosten has developed novel screening methods to match formerly ‘orphan’ G-protein coupled receptors (GPCRs) to their cognate ligands, an important step in identifying their role in biologic and disease processes. She is using these findings to study the role of GPCRs in diabetes-associated microvascular dysfunction and in central circuits underlying obesity-associated hypertension.
Keywords:Hypertension, Diabetes, Obesity