Autoimmunity, Inflammation, and Cancer
Edwin Antony Ph.D.
Edwin Antony utilizes biophysical and biochemical approaches to understand enzyme kinetics, structure, and function during DNA repair and electron transfer. These foundational studies inform on methods to treat and prevent cancer. His lab is also advancing the use of non-canonical amino acids for studying enzyme assembly during DNA repair.
Keywords:Chemotherapeutics, Fluorescent Tools for Protein Research
Chris Arnatt Ph.D.
Chris Arnatt utilizes organic and synthetic chemistry to generate targeted small molecules for research and therapy. He has a special interest in developing chemical and fluorescent probes to study biologic systems, and focuses his research on nuclear proteins and DNA modifications in cancer and stem cell biology.
Keywords:Breast Cancer, GPCRs, Synthetic Chemistry
Rajeev Aurora studies mechanisms that lead to chronic inflammation in the context of osteoimmunology, osteoarthritis, and bone degeneration. His lab uses mouse models and human studies, employing computational and laboratory tools to understand the genetic, epigenetic, and environmental factors that lead from acute inflammation to chronic activation of the immune system. He holds multiple patents on treatments for bone degeneration diseases.
Keywords:Osteoporosis, Acute and Chronic Inflammation, Epigenetics
Colin Flaveny studies the role of the Liver-X-Receptor in regulating metabolic pathways that direct tumorigenesis and modulate tumor immune interactions. His studies have demonstrated promise for targeting the LXR receptor and related pathway for treatment of immune-suppressive solid tumors such as triple-negative breast cancer. Additional work focuses on the role of the Rev-erba protein in lipid metabolism and muscle atrophy.
Keywords: Cancer, Myopathy
Sergey Korolev Ph.D.
Sergey Korolev uses structural, biochemical, and molecular biology methods to study the structure and function of DNA recombination mediatorar proteins. Human RMPs include tumor suppressors BRCA1/2 and PALB2, while pathogen RMPs mediate drug resistance. His lab also studies the calcium-independent phospholipase iPLA2B, a protein implicated in obesity, cancer, and neurodegeneration including Parkinsons.
Keywords: Chronic Pain, Parkinson’s, Tumor Supression
Nicola Pozzi, Ph.D
Nicola Pozzi utlizes biochemical and biophysical techniques to generate dynamic structure-function models of proteins. His lab then employs this knowledge in the design of novel compounds and biologics to treat and diagnose disease. His current work focuses on the structures of proteins involved in Antiphospholipid Syndrome (APS), as well as the role of protein disulfide isomerases in thrombosis, cancer, and neurodegeneration.
Keywords:Autoimmunity, Cardiovascular Disease, Thrombosis
Ryan Teague, Ph.D
Ryan Teague’s laboratory studies and therapeutically targets the molecular mechanisms regulating induction of T cell tolerance to cancer cells, as well as the mechanisms behind T cell reinvigoration after immunotherapy. Similarly, his lab studies induction of cellular immune tolerance in obesity and it’s relationship to cancer, and therapeutic avenues to overcome these limitations.
Keywords:Cancer, Obesity, Tumor Immunology
Silviya Petrova Zustiak, Ph.D.
Silviya Zustiak researches hydrogel biomaterials and tissue engineering, developing novel cell scaffold, drug screening, and drug delivery platforms. 3D Biomaterial-based models are crucial for closing the reproducibility gap between 2D tissue culture and animal models by providing a cell environment that mimics real tissue. This research is highly multidisciplinary, merging engineering, materials science, and biology.
Keywords:Hydrogels, Glioblastoma, Cartilage, Tissue Engineering